منابع مشابه
Toxicology of haloacetonitriles.
Haloacetonitriles are by-products of water chlorination and may form in vivo from the reaction of residual chlorine with endogenous compounds such as amino acids. Dibromoacetonitrile (DBAN) was negative in selected mutagenic assays; dichloroacetonitrile (DCAN) was mutagenic in S. typhimurium, but not in S. cerevisiae. Both DBAN and DCAN may be carcinogenic. There is a paucity of basic toxicolog...
متن کاملHaloacetonitriles: metabolism, genotoxicity, and tumor-initiating activity.
Haloacetonitriles (HAN) are drinking water contaminants produced during chlorine disinfection. This paper evaluates metabolism, genotoxicity, and tumor-initiating activity of these chemicals. The alkylating potential of the HAN to react with the electrophile-trapping agent, 4-(p-nitrobenzyl)pyridine, followed the order dibromoacetonitrile (DBAN) greater than bromochloroacetonitrile (BCAN) great...
متن کاملA review of Novichok Toxicology
Introduction: Novichoks are considered as the fourth generation of chemical weapons and nerve agents (NA) category. NAs were produced and developed during the Cold War in the (former) Soviet :union:. Due to the confidentiality of the manufacturing process of these agents, there is little information about the properties of these compounds. Like other NA, novichoks are organophosphorus compounds...
متن کاملPharmacology and Toxicology of Leflunomide
Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...
متن کاملEmpowerment of Medical Toxicology in South Korea
In a recent issue of the Asia Pacific Journal of Medical Toxicology (APJMT), the importance of empowering medical toxicology in the Asia Pacific Region has been discussed. In the editorial by Dr. Afshari, it has been stated that national societies of medical toxicology are important infrastructure for the development of medical toxicology, and the Asia Pacific Association of Medical Toxicology ...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1986
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.8669183